Sophoraflavanone G

Research use only, not for human use.

Sophoraflavanone G (Kushenol F) isolated from Sophora flavescens induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.

Sophoraflavanone G (Kushenol F) isolated from Sophora flavescens induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.

Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells?in a dose-dependent manner.Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome?c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathwaySophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of29.7 ± 5.2μM.

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Kushenol F | Vexibinol

Apoptosis

Apoptosis

Apoptosis

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97938-30-2

424.5

C25H28O6

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (588.94 mM)

CC(C)=CC[C@H](Cc(c(O[C@@H](CC1=O)c(ccc(O)c2)c2O)c1c(O)c1)c1O)C(C)=C

4H-1-Benzopyran-4-one 23-dihydro-57-dihydroxy-2-(24-dihydroxyphenyl)-8-(5-methyl-2-(1-methylethenyl)-4-hexenyl)- (S-(R*S*))-

(-20℃)

With Ice Pack

≥ 2 years